The Working Hypothesis
Through initial test from R. Kluge (1986) abnormal amino acid distribution in liquor, serum and urine was confirmed. Taking into account the geographic accumulation of MS there were indications of a possible food influence[1]. Additionally there were vague indications of a genetic disposition where the possible genetics of here dity has to be passed on through the mother. Together with these indications, from past neuro biological and neuro chemical trials (D. Biesold, H. MATTHIES und F. HUCHO [2,3]) successive presentations were developed as a working hypothesis.
The reduction of the myelin sheath and the axone followed in intervals and in expansion only a localised level. A result of this was that the infection could not spread further but was stopped by a defence mechanism. This standstill is explained by Matthies* as a new arrangement of the microglia. The spot-shaped inflammation is not contradictory to the experimentally secured results, which through the demyelination freed A1 protein (myelin base protein) produced the effect of an experimental allergic enzephalitis. This is why an automated reaction cannot be ruled out. Furthermore, structural, surrounding effects and effectiveness have to be taken into consideration as the energetic impoverishment of the cells is classed as an important prerequisite for the outbreak of MS, as well as the ambivalent of the immune suppression.
We are proceeding with the assumption of a low functioning of the mitochondrial ornithine cycle (liver, bowel, muscles, microglia). This explains the passing on of the genetic disposition through the hereditary factor of the mother. (Hereditary information of the mitochondrial is in principle only inherited through the mother’s side). In the ornithine cycle, which is part of the urinary substance cycle, the neuro toxic ammonia will be eliminated (detoxication reaction). If there is an obstruction of the reduction of the ammonia in the mitochondrial, this leeds to an accumulation of neuro toxic products and to an energetic impoverishment of the cell.
The genetic anchoring of these cell functions, which are responsible for the interreaction with the mitochondrial, lies in the X chromosome of the cell nucleus. This chromosome is also coded with a control function, which obviously has a special meaning for MS. This control function determines special transport processes, which are energetically dependent. The X chromosome foundations could explain certain tendencies and differences between men and women in Kluge’s therapy. At the same time the mentioned chromosome control functions are influenced extra cellular. Chronobiology, especially the chronoimmunology adds this in all its facets.
R. Kluge and T.H. Schmidt point-out from an early stage of the relatively independent immune system of the bowel. If it is possible to stabilise the bowel functions of an MS patient, so that the autonomous immune system of the bowel influences the whole immune system, a somewhat overreactive immune reaction could be harmonised.
R. Kluge uses Lactulose, which at the same time has an anti-inflammatory effect towards the ammonia. His therapy experiments confirm this assumptions. The regulation of the metabolic formation of ammonia represents the metabolic components of the Kluge therapy. This influence could be confirmed through the food intake of pure ammonia acid mixes on the one hand and an individually adapted protein diet on the other[4].
As well as the metabolic and the immunological influenced autoagression there are other negative factors of the stressors. All these factors work individually and very differently together.
Picture 1: The influential factors in the development of MS
Whilst the influence of the stressors and the autoagression were else where sufficiently described, the influences of the metabolic and the chrono immunology were largely unknown.
There were ideas that a protein reduced diet could influence MS in a positive way but success and an effective repression of the disease didn’t come about.
The working hypothesis of the Kluge therapy is based on a critical evaluation from established ideas and interdisciplinary working methods. R. Kluges own attempts and therapy attempts confirm that MS has also metabolic components.